Hi and welcome to Dr. Francois Major’s laboratory at the Institute for Research in Immunology and Cancer, and Computer Science Department, University of Montreal.

Note: If you are looking for the Supplemental Information of our publications, go to Publications.

Research

In this lab in the long-terms, we want to understand and characterize human gene regulatory networks; link cell content to phenotypes; and, design and create artificial molecular components to peek and poke cell information and programmes.

Software

We are developing a suite of programs to analyze, model, predict, and determine RNA 2D and 3D structure. You can access and download our software through the MC-Tools page. You can also access Web services of most of our programs through the MC-Pipeline page.

Funding News

Septembre 13 2016Genome Canada and Canadian Institutes of Health Research – 16 canadian projects canadiens in bioinformatcs and computational biology (B/CB) were approved for financing, including our project “Computation of cell-specific microRNA::Mrna regulatory networks enables the design of efficient RNAi-based therapeutics”, which received $250,000 over two years.

August 7 2015Cancer Research Society – Spring 2015 Operating Grants Funding Program approved $120,000 over two years: “Deciphering and targeting the gene interaction networks that shape cancer cells ”

April 17 2014Natural Sciences and Engineering Research Council of Canada – Fall 2013 Discovery Grant competition approved $265,000 over five years: “Computational analysis and modeling of noncoding ribonucleic acid structure and function”

April 2 2014Natural Sciences and Engineering Research Council of Canada – Fall 2013 Discovery Grant competition approved $265,000 over five years: “Computational analysis and modeling of noncoding ribonucleic acid structure and function”

April 18 2011Fonds de recherche nature et technologie – Team research project approved $207,000 over three years – : “Computational methods to predict RNA mutations that affect tertiary structure” (with co-applicant Jérôme Waldispuhl, McGill)

May 25 2010National Institutes of Health – National Institute of General Medical Sciences approved $830,494 over five years – : “Computational prediction of RNA 3D structure using low resolution data and a new RNA folding algorithm”

June 30 2009Canadian Institutes of Health Research – Spring 2009 HIV/AIDS Research Initiative – Biomedical/Clinical Stream approved $379,498 over three years: “Developing and testing small RNA-based multiple-target gene therapies against cancer and AIDS” (with co-applicant Gerardo Ferbeyre, biochemistry department)

November 19 2008Canadian Foundation for Innovation – Leaders Opportunity Fund in Multidisciplinary Health Research approved $800,434 for the infrastructure of the “RNA Engineering Laboratory” (with co-applicant Gerardo Ferbeyre, biochemistry department)

January 30 2009Canadian Institutes of Health Research – Fall 2008 Operating Grant competition approved $576,945 over five years: “Computational and structural studies of gene silencing mechanisms”

March 24 2009Human Frontier Science Program – 2008 Research Grant competition approved $USD 1,200,000 over three years: “RNA folding as a mediator of stress response in plants” (with three international co-applicants)

April 17 2009Natural Sciences and Engineering Research Council of Canada – Fall 2008 Discovery Grant competition approved $240,000 over five years: “Computerized analysis and prediction of RNA structure and function”